Anti-Ce complicating two consecutive pregnancies with increasing severity of haemolytic disease of the newborn.

Ranasinghe, E; Goodyear, E; Burgess, G

Ranasinghe, E; Goodyear, E; Burgess, G.

Afiliación

Ranasinghe E; Red Cell Immunohaematology Antenatal Service, National Blood Service, Cambridge, UK. edmund.ranasinghe@nbs.nhs.uk

Transfus Med ; 13(1): 53-5, 2003 Feb.

Article en En | MEDLINE | ID: mdl-12581455

RESUMEN

The Ce antigen is expressed on red cells of individuals with Rh haplotypes, R1 or CDe and r' or Cde. However, anti-Ce is rare, and only two cases of severe haemolytic disease of the newborn (HDN) caused by this antibody have been described (Malde et al., 2000; Wagner et al., 2000). We describe a woman who was found to have anti-Ce in her second pregnancy, resulting in a neonate with HDN that required exchange transfusion. She subsequently had a twin pregnancy, where both the twins were affected by severe haemolytic disease (HD) of the fetus because of anti-Ce and required repeated fetal transfusions, followed by exchange transfusions after birth. This is the first reported case of HD caused by anti-Ce requiring fetal transfusions.

Asunto(s)

Eritroblastosis Fetal/inmunología; Glicoproteínas/inmunología; Sistema del Grupo Sanguíneo Rh-Hr/inmunología; Adulto; Transfusión Sanguínea; Enfermedades en Gemelos; Eritroblastosis Fetal/etiología; Eritroblastosis Fetal/terapia; Femenino; Glicoproteínas/análisis; Humanos; Embarazo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema del Grupo Sanguíneo Rh-Hr / Glicoproteínas / Eritroblastosis Fetal Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Transfus Med Asunto de la revista: HEMATOLOGIA Año: 2003 Tipo del documento: Article Pais de publicación: Reino Unido

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