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Secondary acute myelogenous leukemia with MLL gene rearrangement following radioimmunotherapy (RAIT) for non-Hodgkin's lymphoma.
Nabhan, C; Peterson, L A; Kent, S A; Tallman, M S; Dewald, G; Multani, P; Gordon, L I.
Afiliación
  • Nabhan C; Division of Hematology/Oncology, Department of Medicine, Northwestern University Medical School and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA. c-nabhan@northwestern.edu
Leuk Lymphoma ; 43(11): 2145-9, 2002 Nov.
Article en En | MEDLINE | ID: mdl-12539741
Targeted therapy with conjugated and unconjugated monoclonal antibodies for non-Hodgkin's lymphoma has revolutionized the approach to this disease. The efficacy and low toxicity of these agents have allowed introduction of this strategy in the early stages of therapy. Longer follow-up is needed before validating the safety of these agents. Since monoclonal antibodies are being given as front-line therapy, it is important to identify all potential adverse events. We report a case of secondary acute myelogenous leukemia (AML) with 11q23 cytogenetic abnormality and mixed lymphoid leukemia (MLL) gene expression in a patient treated with Y90 labeled anti-CD20 antibody (Zevalin). The patient was not exposed to topoisomerase II inhibitors. Our observations suggest a relationship between 11q23 leukemia and radioimmunotherapy (RAIT) and further studies are needed.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Linfoma no Hodgkin / Proto-Oncogenes / Leucemia Mieloide Aguda / Radioinmunoterapia / Neoplasias Primarias Secundarias / Proteínas de Unión al ADN Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2002 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Buscar en Google
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Imprimir
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Linfoma no Hodgkin / Proto-Oncogenes / Leucemia Mieloide Aguda / Radioinmunoterapia / Neoplasias Primarias Secundarias / Proteínas de Unión al ADN Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2002 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos