The efficacy of intravitreal levofloxacin and intravitreal dexamethasone in experimental Staphylococcus epidermidis endophthalmitis.
Ophthalmic Res
; 34(6): 349-56, 2002.
Article
en En
| MEDLINE
| ID: mdl-12483022
This study was designed to investigate the efficacy of intravitreal levofloxacin, and intravitreal levofloxacin and dexamethasone combined in Staphylococcus epidermidis endophthalmitis. Albino rabbits (n = 25), infected with an intravitreal inoculum of S. epidermidis (1.0 x 10(5) colony forming units/0.1 ml), were divided into five groups (n = 5). Groups 1 and 2 received treatment 24 h after the inoculation, and groups 3 and 4 48 h after the inoculation. No treatment was given to the control group. Treatment efficacy was assessed by vitreous culture, clinical examination and histopathology. Five days after treatment, groups 1 and 2 had significantly lower clinical scores than the control group (p = 0.004, p = 0.007). The culture results of the treatment groups were sterile. The histopathological scores of the treatment groups were lower than the control group (p = 0.007). Studies on retinal toxicity and dose-response relation are needed to prove the efficacy of levofloxacin in S. epidermidis endophthalmitis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Staphylococcus epidermidis
/
Dexametasona
/
Ofloxacino
/
Endoftalmitis
/
Levofloxacino
/
Antiinfecciosos
/
Antiinflamatorios
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Ophthalmic Res
Año:
2002
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Suiza