Gas chromatography/mass spectrometric study of non-commercial C-4-substituted 1,4-dihydropyridines and their oxidized derivatives.
Rapid Commun Mass Spectrom
; 16(24): 2229-38, 2002.
Article
en En
| MEDLINE
| ID: mdl-12478565
A gas chromatography/mass spectrometry (GC/MS) method for the qualitative and quantitative determination of the calcium-channel antagonists C-4-substituted 1,4-dihydropyridines, and their corresponding N-ethyl derivatives, is presented. Also, the electrochemical oxidation and the reactivity of the compounds with alkyl radicals derived from 2,2'-azobis-(2-amidinopropane) were monitored by GC/MS. Mass spectral fragmentation patterns for the C-4-substituted 1,4-dihydropy-ridine parent drugs were significantly different from those of their oxidation products, generated either by electrochemical oxidation or by reaction with alkyl radicals. However, for N-ethyl-1,4-dihydropyridine compounds it was not possible to detect the final products (pyridinium salts) using these experimental conditions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dihidropiridinas
/
Bloqueadores de los Canales de Calcio
Tipo de estudio:
Qualitative_research
Idioma:
En
Revista:
Rapid Commun Mass Spectrom
Año:
2002
Tipo del documento:
Article
País de afiliación:
Chile
Pais de publicación:
Reino Unido