Pine resin and biopin ointment: effects of water-soluble fractions on cytokine production by peripheral blood neutrophils.

Simbirtsev, A S; Konusova, V G; McHedlidze, G Sh; Paramonov, B A; Chebotarev, V Yu

Simbirtsev, A S; Konusova, V G; McHedlidze, G Sh; Paramonov, B A; Chebotarev, V Yu.

Afiliación

Simbirtsev AS; Institute of High-Purity Biological Preparations, St. Petersburg.

Bull Exp Biol Med ; 134(2): 151-5, 2002 Aug.

Article en En | MEDLINE | ID: mdl-12459838

RESUMEN

We studied the effects of water-soluble fractions of pine resin and Biopin-10 and Biopin-20 ointments used for the therapy of burns, wounds, and purulent and inflammatory diseases on spontaneous and induced synthesis of tumor necrosis factor and interleukins 1, 2, and 8 by human peripheral blood neutrophils in vitro. These preparations contain various bioactive substances producing opposite and dose-dependent immunomodulatory effects. Our results indicate that the composition and doses of preparations should be selected to achieve the maximum therapeutic effect.

Asunto(s)

Biopterinas/farmacología; Interleucinas/biosíntesis; Neutrófilos/efectos de los fármacos; Pomadas; Resinas de Plantas/farmacología; Factor de Necrosis Tumoral alfa/biosíntesis; Biopterinas/administración & dosificación; Humanos; Neutrófilos/metabolismo; Resinas de Plantas/administración & dosificación

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pomadas / Resinas de Plantas / Biopterinas / Interleucinas / Factor de Necrosis Tumoral alfa / Neutrófilos Límite: Humans Idioma: En Revista: Bull Exp Biol Med Año: 2002 Tipo del documento: Article Pais de publicación: Estados Unidos

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