Use of isolated mature osteoblasts in abundance acts as desired-shaped bone regeneration in combination with a modified poly-DL-lactic-co-glycolic acid (PLGA)-collagen sponge.
J Cell Physiol
; 194(1): 45-53, 2003 Jan.
Article
en En
| MEDLINE
| ID: mdl-12447988
Controlled regeneration of bone or cartilage has recently begun to facilitate a host of novel clinical treatments. An osteoblast line, which we isolated is able to form new bone matrix in vivo within 2 days and exhibits a mature osteoblast phenotype both in vitro and in vivo. Using these cells, we show that cuboidal bones can be generated into a predesigned shaped-bone with high-density bone trabeculae when used in combination with a modified poly-DL-lactic-co-glycolic acid (PLGA)-collagen sponge. PLGA coated with collagen gel serves as a good scaffold for osteoblasts. These results indicate that mature osteoblasts, in combination with a scaffold such as PLGA-collagen sponge, show promise for use in a custom-shaped bone regeneration tool for both basic research into osteogenesis and for development of therapeutic applications.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoblastos
/
Regeneración Ósea
/
Células de la Médula Ósea
/
Trasplante de Tejidos
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Células del Estroma
/
Técnicas de Cultivo de Célula
/
Ingeniería de Tejidos
Límite:
Animals
Idioma:
En
Revista:
J Cell Physiol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos