Microwave-assisted (radio)halogenation of nitroimidazole-based hypoxia markers.

Kumar, P; Wiebe, L I; Asikoglu, M; Tandon, M; McEwan, A J B

Kumar, P; Wiebe, L I; Asikoglu, M; Tandon, M; McEwan, A J B.

Afiliación

Kumar P; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.

Appl Radiat Isot ; 57(5): 697-703, 2002 Nov.

Article en En | MEDLINE | ID: mdl-12433044

RESUMEN

Microwave-assisted radiohalogenation for the production of short-lived radiopharmaceuticals has now been applied to the synthesis and radiolabelling of azomycin nucleosides. (Radio)halogens were incorporated either by nucleophilic substitution of a leaving group or by halogen-halogen exchange, in the synthesis of IAZA, IAZP and FAZA. A comparison of conventional labelling and microwave-assisted labelling procedures reflects a clear advantage of the microwave technique.

Asunto(s)

Hipoxia/diagnóstico por imagen; Radioisótopos de Yodo; Marcaje Isotópico/métodos; Nitroimidazoles/síntesis química; Radiofármacos/síntesis química; Biomarcadores; Calor; Humanos; Microondas; Radioquímica/métodos; Cintigrafía

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiofármacos / Radioisótopos de Yodo / Marcaje Isotópico / Hipoxia / Nitroimidazoles Límite: Humans Idioma: En Revista: Appl Radiat Isot Asunto de la revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Año: 2002 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

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