TCR gene-rearranged, extranodal NK/T-cell lymphoma, nasal type, presenting as gyrate patches.
J Dermatol
; 29(10): 648-52, 2002 Oct.
Article
en En
| MEDLINE
| ID: mdl-12432997
In the CD56+ cutaneous nasal-type NK/T-cell lymphoma strongly associated with latent EBV infection, subcutaneous or dermal nodules are the most common skin findings, but great morphologic heterogeneity has been noted including papules, infiltrated plaques, and ulcerated tumors, and TCR genes are mostly germline. We describe a case of nasal and nasal-type NK/T-cell lymphoma featuring multiple erythematous polycyclic patches on the trunk, which is similar to patch stage mycosis fungoides or other cutaneous T cell lymphoma. Immunohistochemical study of a skin biopsy specimen revealed CD2+, CD3epsilon+, CD56+, and CD45RO+ expression in the neoplastic cells. In situ hybridization using an anti-sense Epstein Barr virus early regions probe showed a positive reaction. However, clonal TCR beta gene rearrangement was found.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Neoplasias Nasales
/
Linfoma de Células T
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Dermatol
Año:
2002
Tipo del documento:
Article
Pais de publicación:
Reino Unido