Miswiring of limbic thalamocortical projections in the absence of ephrin-A5.
J Neurosci
; 22(21): 9352-7, 2002 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-12417660
Axon guidance cues of the ephrin ligand family have been hypothesized to regulate the formation of thalamocortical connections, but in vivo evidence for such a role has not been examined directly. To test whether ephrin-mediated repulsive cues participate in sorting the projections originating from distinct thalamic nuclei, we analyzed the organization of somatosensory and anterior cingulate afferents postnatally in mice lacking ephrin-A5 gene expression. Projections from ventrobasal and laterodorsal nuclei to their respective sensory and limbic cortical areas developed normally. However, a portion of limbic thalamic neurons from the laterodorsal nucleus also formed additional projections to somatosensory cortical territories, thus maintaining inappropriate dual projections to multiple cortical regions. These results suggest that ephrin-A5 is not required for the formation of normal cortical projections from the appropriate thalamic nuclei, but rather acts as a guidance cue that restricts limbic thalamic axons from inappropriate neocortical regions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tálamo
/
Corteza Cerebral
/
Efrina-A5
/
Sistema Límbico
/
Malformaciones del Sistema Nervioso
Límite:
Animals
Idioma:
En
Revista:
J Neurosci
Año:
2002
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos