Platelet monoamine oxidase activity in alcoholism subtypes: relationship to personality traits and executive functions.
Alcohol Alcohol
; 37(6): 597-602, 2002.
Article
en En
| MEDLINE
| ID: mdl-12414554
AIMS: The purpose of the present study was to compare alcoholic subtypes (type 1 versus type 2) with regard to platelet monoamine oxidase (MAO) activity. A possible relationship between enzyme activity, personality traits and executive functions was also investigated. METHODS: Seventeen type 1 and 16 type 2 in-patient male chronic alcoholic patients and 17 healthy male volunteers were included in the study. The personality traits were investigated by the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). Executive functions were assessed by the Wisconsin Card Sorting Test (WCST). RESULTS: When compared to the healthy subjects, platelet MAO activity was reduced in both alcoholic groups. The enzyme activity of the type 2 group was significantly lower than that of type 1 patients. Both groups of alcoholic patients also displayed impairment in executive functions. The comparison of the MMPI-2 scores of the study groups revealed that type 2 alcoholics had more severe psychopathology. CONCLUSIONS: The results support previous evidence suggesting that platelet MAO activity is a useful biochemical measure for the subtyping of alcoholics.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos de la Personalidad
/
Plaquetas
/
Alcoholismo
Límite:
Adult
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Alcohol Alcohol
Año:
2002
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Reino Unido