Apigenin--strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo.
Phytomedicine
; 9(6): 489-95, 2002 Sep.
Article
en En
| MEDLINE
| ID: mdl-12403156
The cancer chemopreventive agent apigenin also has strong cytostatic and anti-angiogenic effects in vitro. We now investigated its efficacy against experimental Lewis lung carcinomas (LLC), C-6 gliomas and DHDK 12 colonic cancers in vivo. Tumour bearing mice received 50 mg/kg/day apigenin in three different galenical formulations during 12 days in 8-hourly intervals. Only weak effects of apigenin on the size and the number of new tumour blood vessels of both established and newly transplanted tumours were recorded although the intratumoural necrosis was elevated (45 +/- 15% vs. 20 +/- 7% (control), p < 0.05%). These results contrast sharply with the high in vitro sensitivity of LLC, C-6, DHDK 12 and endothelial cells to apigenin where complete growth suppression occurs at concentrations beyond 30 g/ml. Possible causes are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
Phytomedicine
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2002
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania