Dysfunction of myocardial and vascular taurine transport in spontaneously hypertensive rats.
Sheng Li Xue Bao
; 54(5): 359-64, 2002 Oct 25.
Article
en En
| MEDLINE
| ID: mdl-12399812
The alterations of taurine transport and the expression of taurine transporter (TAUT) mRNA in myocardium and aortic wall were investigated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. It was demonstrated that plasma taurine concentration and taurine release from myocardium and aortic wall in SHR were higher than those in WKY rats, whereas taurine content, taurine uptake and TAUT mRNA in myocardium and aortic wall of SHR were lower than those of WKY rats. In SHR, the maximal velocity (V(max)) of taurine transportation in myocardium and aortic wall was lower by 24% (P<0.05) and 35% (P<0.05) than that in WKY, their michaelis constants (Km) values were higher by 16% (P<0.05) and 39% (P<0.05), respectively. The results suggest that there is dysfunction of taurine transport in myocardium and aortic wall in SHR, which may be partly resulted from the decrease of TAUT activity and affinity, and down-regulation of TAUT gene expression.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Taurina
/
Vasos Sanguíneos
/
Proteínas Portadoras
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
Sheng Li Xue Bao
Año:
2002
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China