Modulation of brain stem monoamines and gamma-aminobutyric acid by NK1 receptors in rats.
Neuroreport
; 13(14): 1809-12, 2002 Oct 07.
Article
en En
| MEDLINE
| ID: mdl-12395129
To understand the role of substance P in stress, anxiety and depression, we have investigated in rats the relationship between NK1 receptors and monoamines or GABA, and between substance P and serotonin (5-HT) in brain stem neurons by immunohistochemical double-staining techniques. In the periaqueductal gray and dorsal raphe nucleus, there was no colocalization between NK1 and 5-HT or between NK1 and tyrosine hydroxylase (a marker for adrenaline and dopamine neurons). However, many GABA-positive neurons (> 50%) were NK1 positive, and some substance P-positive neurons were 5-HT positive as well. Almost all locus coeruleus noradrenaline neurons were NK1 positive. Therefore, substance P may promote stress by activating noradrenaline neurons directly and inhibiting 5-HT neurons indirectly via GABA neurons.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
/
Sustancia Gris Periacueductal
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Núcleos del Rafe
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Monoaminas Biogénicas
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Receptores de Neuroquinina-1
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Ácido gamma-Aminobutírico
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
2002
Tipo del documento:
Article
Pais de publicación:
Reino Unido