Antimutagenic activities of acetone and methanol fractions of Terminalia arjuna.

Kaur, K; Arora, S; Kumar, S; Nagpal, A

Kaur, K; Arora, S; Kumar, S; Nagpal, A.

Afiliación

Kaur K; Department of Botanical Land Environmental Sciences, Guru Nanak Dev University, Amritsar, India. kamal_rajjput@hotmail.com

Food Chem Toxicol ; 40(10): 1475-82, 2002 Oct.

Article en En | MEDLINE | ID: mdl-12387312

RESUMEN

The antimutagenic effect of benzene, chloroform, acetone and methanol fractions from Terminalia arjuna, a well-known medicinal plant, was determined against Acid Black dye, 2-aminofluorene (2AF) and 4-nitro-o-phenylenediamine (NPD) in TA98 Frameshift mutagen tester strain of Salmonella typhimurium. Among the different fractions, the antimutagenic effect of acetone and methanol fractions was more than that observed with other fractions. Co-incubation and pre-incubation modes of experimentation did not show much difference in the antimutagenic activity of the extracts. Moreover, these fractions inhibited the S9-dependent mutagens, 2AF and Acid Black dye more effectively than the direct-acting mutagens. Studies are under way to isolate and elucidate the nature of the antimutagenic factor in acetone and methanol fractions.

Asunto(s)

Acetona; Antimutagênicos/farmacología; Metanol; Extractos Vegetales/farmacología; Terminalia/química; Colorantes/toxicidad; Fluorenos/antagonistas & inhibidores; Fluorenos/toxicidad; Pruebas de Mutagenicidad; Mutágenos/toxicidad; Fenilendiaminas/antagonistas & inhibidores; Fenilendiaminas/toxicidad; Corteza de la Planta/química

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetona / Extractos Vegetales / Antimutagênicos / Terminalia / Metanol Idioma: En Revista: Food Chem Toxicol Año: 2002 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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