Sex hormone-binding globulin is synthesized in target cells.

Kahn, S M; Hryb, D J; Nakhla, A M; Romas, N A; Rosner, W

Kahn, S M; Hryb, D J; Nakhla, A M; Romas, N A; Rosner, W.

Afiliación

Kahn SM; Department of Medicine, St Luke's/Roosevelt Hospital Center, and College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA. wr7@columbia.edu

J Endocrinol ; 175(1): 113-20, 2002 Oct.

Article en En | MEDLINE | ID: mdl-12379495

RESUMEN

Sex hormone-binding globulin (SHBG) is a multifunctional protein that acts in humans to regulate the response to steroids at several junctures. It was originally described as a hepatically secreted protein that is the major binding protein for sex steroids in plasma, thereby regulating the availability of free steroids to hormone-responsive tissues. SHBG also functions as part of a novel steroid-signaling system that is independent of the classical intracellular steroid receptors. Unlike the intracellular steroid receptors that are ligand-activated transcription factors, SHBG mediates androgen and estrogen signaling at the cell membrane by way of cAMP. We have reviewed the current state of knowledge on the SHBG gene and the role of SHBG in steroid signaling (we shall not address its function as a plasma-binding protein).

Asunto(s)

Hígado/metabolismo; Globulina de Unión a Hormona Sexual/biosíntesis; Transducción de Señal/fisiología; Andrógenos/metabolismo; Estrógenos/metabolismo; Trompas Uterinas/metabolismo; Femenino; Humanos; Masculino; Próstata/metabolismo; Receptores de Superficie Celular/metabolismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Globulina de Unión a Hormona Sexual / Transducción de Señal / Hígado Límite: Female / Humans / Male Idioma: En Revista: J Endocrinol Año: 2002 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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