Peculiarities of adrenergic regulation of smooth muscles in rabbit pulmonary arteries.

Kapilevich, L V; Nosarev, A V; D'yakova, E Yu; Kovalev, I V; Baskakov, M B; Anfinogenova, Ya D; Medvedev, M A

Kapilevich, L V; Nosarev, A V; D'yakova, E Yu; Kovalev, I V; Baskakov, M B; Anfinogenova, Ya D; Medvedev, M A.

Afiliación

Kapilevich LV; Siberian State Medical University, Tomsk. kapil@aport.ru

Bull Exp Biol Med ; 133(3): 214-6, 2002 Mar.

Article en En | MEDLINE | ID: mdl-12360333

RESUMEN

Muscle tension recording was used to study adrenergic contractile reactions of pulmonary artery smooth muscles in rabbits. Stimulation of alpha-adrenoceptors induced contraction of pulmonary artery smooth muscle cells. Endothelium partially inhibited the contractile effect of alpha-adrenoceptor agonists. Activation of smooth muscle beta-adrenoceptors in pulmonary arteries produced a dual dose-dependent effect (relaxation at agonist concentrations of 10 nM-1 muM and contraction at concentrations above 10 muM). The contractile effect of beta-adrenoceptor activation in smooth muscle cells is a specific feature of pulmonary arteries probably related to peculiarities of cAMP-signaling in these cells.

Asunto(s)

Músculo Liso Vascular/fisiología; Arteria Pulmonar/fisiología; Receptores Adrenérgicos/fisiología; Agonistas alfa-Adrenérgicos/farmacología; Agonistas Adrenérgicos beta/farmacología; Animales; Epinefrina/farmacología; Técnicas In Vitro; Isoproterenol/farmacología; Contracción Muscular/efectos de los fármacos; Conejos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteria Pulmonar / Receptores Adrenérgicos / Músculo Liso Vascular Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2002 Tipo del documento: Article Pais de publicación: Estados Unidos

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