Cp50 of propofol for laryngeal mask airway insertion using predicted concentrations with and without nitrous oxide.
Anaesthesia
; 57(10): 956-9, 2002 Oct.
Article
en En
| MEDLINE
| ID: mdl-12358953
This study sought to determine the predicted Cp50 of propofol required for laryngeal mask airway insertion (Cp50LMA) and to investigate whether nitrous oxide reduces these required concentrations. Using target-controlled infusion and incorporating the standard Diprifusor pharmacokinetic model, 46 unpremedicated patients were randomly assigned to one of two groups. The patients received either 40% oxygen in air (control group: n = 23), or 60% nitrous oxide in oxygen (nitrous oxide group: n = 23). The target concentration for each patient was determined using the up and down method. Following equilibration between the predetermined blood and effect site concentrations, had been established for > 10 min, laryngeal mask airway insertion was attempted without neuromuscular relaxants. The data were analysed using a probit analysis to obtain Cp50LMA levels. The values for Cp50LMA were 3.24 micro g.ml-1 in the control group and 1.93 microg.ml-1 in the nitrous oxide group.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propofol
/
Máscaras Laríngeas
/
Anestésicos Intravenosos
/
Anestésicos por Inhalación
/
Óxido Nitroso
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Anaesthesia
Año:
2002
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Reino Unido