Epidemiology of venous thromboembolic disease and OC use.
Dialogues Contracept
; 5(1): 4-7, 10, 1996.
Article
en En
| MEDLINE
| ID: mdl-12347722
PIP: A review of recent epidemiologic studies that have detected an association between the use of oral contraceptives (OCs) containing the progestins gestodene and desogestrel and venous thromboembolism (VTE) risk suggests evidence of bias. Reviewed are five major case-control and cohort studies: World Health Organization Collaborative Study, Boston Collaborative Drug Surveillance Program Study, European Transnational Study, and the Leiden Study. Three major sources of bias could account for the increased VTE risk among users of third-generation compared to second-generation OCs: 1) selective prescription of newer formulations to higher-risk women; 2) the increased tendency for women with suspected VTE to be more likely to be referred for diagnostic testing and hospitalization if they are taking the newer OCs rather than older formulations; and 3) attrition of susceptibles. The lack of any proposed biological basis for the observed association between VTE and the new progestins, compared with previous knowledge about the responsibility of estrogen for increased VTE risk, raises additional doubts about the findings. Any evaluation should balance the effects of OCs on overall risk of cardiovascular disease against protection from pregnancy and noncontraceptive health benefits such as a reduced risk of certain cancers.^ieng
Palabras clave
Bias; Biology; Contraception; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Contraceptive Methods--side effects; Desogestrel--side effects; Diseases; Embolism; Epidemiology; Error Sources; Family Planning; Gestodene--side effects; Health; Measurement; Oral Contraceptives--side effects; Public Health; Research Methodology; Risk Factors; Thromboembolism; Vascular Diseases
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tromboembolia
/
Sesgo
/
Epidemiología
/
Factores de Riesgo
/
Desogestrel
/
Anticonceptivos Orales
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Idioma:
En
Revista:
Dialogues Contracept
Año:
1996
Tipo del documento:
Article
Pais de publicación:
Estados Unidos