IgE-mediated allergy to phytase -- a new animal feed additive.
Allergy
; 57(10): 943-5, 2002 Oct.
Article
en En
| MEDLINE
| ID: mdl-12269943
BACKGROUND: Although fungal phytase is frequently used as an additive to animal feed few investigations of its allergenic property have been conducted. METHODS: Fifty-three subjects occupationally exposed to powdered phytase from Aspergillus niger were studied. Exposure data and symptoms were registered by the company physician. RESULTS: Thirty-eight subjects complained of work-related respiratory symptoms and 14 of them showed phytase-specific IgE antibodies; only one asymptomatic subject revealed such antibodies. IgE antibodies were significantly more frequently found in the high-exposure group (technical centre) when compared with the low-exposure group (laboratories, experimental animal husbandry). Phytase-specific IgG antibodies were present in 19 symptomatic (50%) and five (33%) asymptomatic subjects. CONCLUSIONS: Our results demonstrate that powdered fungal phytase is a highly sensitizing substance whose inhalation exposure should be avoided. Hypersensitivity symptoms could be prevented by means of extensive hygienic measures and ongoing medical surveillance.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
6-Fitasa
/
Hipersensibilidad Inmediata
/
Alimentación Animal
Tipo de estudio:
Observational_studies
/
Prevalence_studies
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Risk_factors_studies
Límite:
Adult
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Allergy
Año:
2002
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Dinamarca