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Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome.
Ang, C W; Tio-Gillen, A P; Groen, J; Herbrink, P; Jacobs, B C; Van Koningsveld, R; Osterhaus, A D M E; Van der Meché, F G A; van Doorn, P A.
Afiliación
  • Ang CW; Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands. Ang@bacl.azr.nl
J Neuroimmunol ; 130(1-2): 179-83, 2002 Sep.
Article en En | MEDLINE | ID: mdl-12225900
Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with MP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with MP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Imitación Molecular / Síndrome de Guillain-Barré / Galactosilceramidas / Infecciones por Mycoplasma / Mycoplasma pneumoniae Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Neuroimmunol Año: 2002 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Imitación Molecular / Síndrome de Guillain-Barré / Galactosilceramidas / Infecciones por Mycoplasma / Mycoplasma pneumoniae Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Neuroimmunol Año: 2002 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos