Assessment of the immunocontraceptive effect of a zona pellucida 3 peptide antigen in wild mice.
Reprod Fertil Dev
; 14(3-4): 151-5, 2002.
Article
en En
| MEDLINE
| ID: mdl-12219936
Immunizing laboratory mice against a short peptide to mouse zona pellucida protein 3 (mZP3; amino acids 328-342) reduces fertility in some strains. This antigen was therefore tested to see if it is suitable for use in an immunocontraceptive vaccine to control wild mice. Mouse zona pellucida protein 3 peptide conjugated to a carrier protein (keyhole limpet hemocyanin) was considerably more immunogenic and effective in reducing fertility in wild mice when compared with inbred BALB/c mice. Fertility of the immunized wild mice was reduced by over 50% compared with controls, whereas BALB/c mice showed no reduction. Variation in the responses between individual animals to mZP3 peptide was observed and infertility correlated to the presence of cross-reacting antibodies to native zona pellucida in wild, but not BALB/c, mice.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Proteínas del Huevo
/
Control de Roedores
/
Receptores de Superficie Celular
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Anticoncepción Inmunológica
/
Ratones
/
Antígenos
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Reprod Fertil Dev
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2002
Tipo del documento:
Article
Pais de publicación:
Australia