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Induction of DNA double strand breaks in scid cells by carbon ions.
Shimasaki, T; Ihara, M; Furusawa, Y; Okumura, Y.
Afiliación
  • Shimasaki T; Research Centre for Isotope Science, Kumamoto University, 2-2-1 Honjo, 860-0811 Kumamoto, Japan. tshima@kaiju.medic.kumamoto-u.ac.jp
Radiat Prot Dosimetry ; 99(1-4): 155-7, 2002.
Article en En | MEDLINE | ID: mdl-12194272
The DNA double strand breaks (DSBs) induced by X ray and carbon ion beam irradiation in scid cells were analysed using pulsed-field gel electrophoresis. Scid cells and hybrid cells were ideal to study the DNA DSB repair mechanisms, because their genetic backgrounds were identical except DNA-PK activity. Induction of DNA DSBs was determined after exposure to X rays and carbon beams. DNA DSB repair was by biphasic kinetics with a fast and a slow component. For scid cells only a slow component was observed, whereas the kinetics of DSBs repair was biphasic with a fast and a slow component. It was concluded from the experimental data that the induced DSB rejoining in scid cells was due to the lack of DNA-PK activity.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / ADN / Inmunodeficiencia Combinada Grave / Reparación del ADN Límite: Humans Idioma: En Revista: Radiat Prot Dosimetry Año: 2002 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / ADN / Inmunodeficiencia Combinada Grave / Reparación del ADN Límite: Humans Idioma: En Revista: Radiat Prot Dosimetry Año: 2002 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido