Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway.
Cancer Res
; 62(16): 4583-7, 2002 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-12183411
In 85% of Ewing family tumors, the NH2 terminus of EWS is fused to the DNA-binding domain of FLI1, an ets transcription factor. The resulting chimeric protein is a strong transcriptional activator with transforming activity. We report that EWS and EWS-FLI1 interact via their common NH2 terminus with the COOH terminus of BARD1, a putative tumor suppressor, in vitro and in vivo. Because BARD1 associates via its NH2-terminal RING domain with the breast cancer susceptibility gene BRCA1 that provides a platform for interactions with proteins involved in DNA repair and checkpoint control, our results provide a link between the Ewing's sarcoma gene product and the genome surveillance complex.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ribonucleoproteínas
/
Sarcoma de Ewing
/
Factores de Transcripción
/
Proteínas Portadoras
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Proteínas de Fusión Oncogénica
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Proteínas Supresoras de Tumor
/
Ubiquitina-Proteína Ligasas
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
2002
Tipo del documento:
Article
País de afiliación:
Austria
Pais de publicación:
Estados Unidos