The effects of inhalation of a novel nitric oxide donor, DETA/NO, in a patient with severe hypoxaemia due to acute respiratory distress syndrome.
Anaesth Intensive Care
; 30(4): 472-6, 2002 Aug.
Article
en En
| MEDLINE
| ID: mdl-12180587
Aerosolized NONOates have been investigated in animal models in acute pulmonary hypertension, but none have been used in humans. We report the first use of aerosolized diethylenetriamine nitric oxide adduct (DETA/NO), a NONOate, in a patient with severe acute respiratory distress syndrome. Both pulmonary vascular resistance index and mean pulmonary arterial pressure were reduced by a mean of 26% and 18% respectively after the administration of a single dose of DETA/NO (150 micromol). Intrapulmonary shunting also improved. There were no significant changes in systemic arterial pressure or arterial methaemoglobin concentration after DETA/NO inhalation. We conclude that DETA/NO aerosol produced selective pulmonary vasodilation, with an improvement in pulmonary haemodynamics and oxygenation, while having no measurable effect on the systemic circulation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Poliaminas
/
Síndrome de Dificultad Respiratoria
/
Donantes de Óxido Nítrico
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Anaesth Intensive Care
Año:
2002
Tipo del documento:
Article
Pais de publicación:
Estados Unidos