Toxicity of cylindrospermopsin to the brine shrimp Artemia salina: comparisons with protein synthesis inhibitors and microcystins.

Metcalf, J S; Lindsay, J; Beattie, K A; Birmingham, S; Saker, M L; Törökné, A K; Codd, G A

Metcalf, J S; Lindsay, J; Beattie, K A; Birmingham, S; Saker, M L; Törökné, A K; Codd, G A.

Afiliación

Metcalf JS; Division of Environmental and Applied Biology, School of Life Sciences, University of Dundee, Dundee, DD1 4HN, UK.

Toxicon ; 40(8): 1115-120, 2002 Aug.

Article en En | MEDLINE | ID: mdl-12165313

RESUMEN

The Artemia salina bioassay was successfully applied to the analysis of the hepatotoxic cyanobacterial alkaloid and protein synthesis inhibitor, cylindrospermopsin. A dose-dependent response in mortality was observed for purified cylindrospermopsin and LC(50) values decreased with time from 8.1 to 0.71 microg/ml(-1), between 24 and 72 h, respectively. Cylindrospermopsin was slightly less potent than micro cystin-LR, with similar LC(50) values on a gravimetric basis, but was more toxic to A.salina than the protein synthesis inhibitors, cycloheximide, chloramphenicol and tetracycline. Cylindrospermopsin-containing strains of the cyanobacterium Cylindrospermopsis raciborskii were found to be toxic to A.salina and the LC(50) concentration for these strains over time was greater than the LC(50) for purified cylindrospermopsin, with the exception of C. raciborskii strain CR1.

Asunto(s)

Artemia/fisiología; Cianobacterias/metabolismo; Péptidos Cíclicos/toxicidad; Inhibidores de la Síntesis de la Proteína/toxicidad; Uracilo/análogos & derivados; Uracilo/toxicidad; Alcaloides; Animales; Toxinas Bacterianas; Cromatografía Líquida de Alta Presión; Cianobacterias/química; Toxinas de Cianobacterias; Relación Dosis-Respuesta a Droga; Dosificación Letal Mediana; Toxinas Marinas; Microcistinas; Péptidos Cíclicos/química; Péptidos Cíclicos/aislamiento & purificación; Inhibidores de la Síntesis de la Proteína/química; Uracilo/química; Uracilo/aislamiento & purificación

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Artemia / Uracilo / Inhibidores de la Síntesis de la Proteína / Cianobacterias Límite: Animals Idioma: En Revista: Toxicon Año: 2002 Tipo del documento: Article Pais de publicación: Reino Unido

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