Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate.
Am J Hum Genet
; 71(3): 565-74, 2002 Sep.
Article
en En
| MEDLINE
| ID: mdl-12119601
Genomewide association studies may offer the best promise for genetic mapping of complex traits. Such studies in outbred populations require very densely spaced single-nucleotide polymorphisms. In recently founded population isolates, however, extensive linkage disequilibrium (LD) may make these studies feasible with currently available sets of short tandem repeat markers, spaced at intervals as large as a few centimorgans. We report the results of a genomewide association study of severe bipolar disorder (BP-I), using patients from the isolated population of the central valley of Costa Rica. We observed LD with BP-I on several chromosomes; the most striking results were in proximal 8p, a region that has previously shown linkage to schizophrenia. This region could be important for severe psychiatric disorders, rather than for a specific phenotype.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno Bipolar
/
Cromosomas Humanos Par 8
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Desequilibrio de Ligamiento
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Mapeo Cromosómico
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
America central
/
Costa rica
Idioma:
En
Revista:
Am J Hum Genet
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos