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Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities.
Dogan, Hatice N; Duran, Arzu; Rollas, Sevim; Sener, Göksel; Uysal, Meral K; Gülen, Dumrul.
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  • Dogan HN; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, 81010 Haydarpasa, Istanbul, Turkey. nesedogan19@hotmail.com
Bioorg Med Chem ; 10(9): 2893-8, 2002 Sep.
Article en En | MEDLINE | ID: mdl-12110309
Two new series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized for their possible anticonvulsant, antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100mg/kg i.p. against pentylenetetrazole-induced convulsions in mice ranged from 0 to 90%. Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiadiazoles / Antibacterianos / Anticonvulsivantes Límite: Animals Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2002 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiadiazoles / Antibacterianos / Anticonvulsivantes Límite: Animals Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2002 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido