[Optimization of dosing of finlepsin and finlepsin-retard in patients with partial epilepsy on the basis of population modeling and drug monitoring]. / Optimizatsiia dozirovaniia preparatov finlepsin i finlepsin-retard u bol'nykh partsial'noi épilepsiei na osnove populiatsionnogo modelirovaniia i lekarstvennogo monitoringa.
Zh Nevrol Psikhiatr Im S S Korsakova
; 102(6): 15-20, 2002.
Article
en Ru
| MEDLINE
| ID: mdl-12101888
Taking into account the drug monitoring data, twenty-six patients with partial epilepsy were treated with finlepsin (carbamazepin) and finlepsin-retard. According to the therapy, the patients were grouped as following: 11 patients were taking finlepsin, 10--finlepsin-retard and 5 were first treated with finlepsin and then, because of the lack of the effect, assigned to finlepsin-retard. The seizures severity was assessed using special seizures severity scale. Better clinical results (remission and reduction of seizures severity) were found in patients treated with finlepsin-retard as compared to those from other groups. Due to monitoring, a remission was reached using the lower finlepsin dosage. The authors confirm individuality of pharmacokinetic parameters, a need in precise individual treatment strategy and a necessity for controlling drug levels in plasma after replacing one form for another.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carbamazepina
/
Epilepsias Parciales
/
Anticonvulsivantes
Tipo de estudio:
Screening_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Zh Nevrol Psikhiatr Im S S Korsakova
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2002
Tipo del documento:
Article
Pais de publicación:
Rusia