An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis.
Acta Psychiatr Scand
; 106(1): 71-4; discussion 74-5, 2002 Jul.
Article
en En
| MEDLINE
| ID: mdl-12100350
OBJECTIVE: Case of an interstitial deletion of the long arm of chromosome 21 presenting with first episode of psychosis. METHOD: A case report. RESULTS: A 16-year-high school student of Somalian origin presented with a first episode of psychosis, mild mental retardation and dysmorphic features. Chromosome analysis revealed an interstitial deletion in the long arm of chromosome 21, described as 46, XX del (21) (q21q22.1). CONCLUSION: First episode of psychosis occurred in combination with neurobiological vulnerability and a complex genetic inheritance. The occurrence of psychosis in our case may be attributable to genes located within the region 21q21q22.1. The possibility that other loci exist on chromosome 21, which predispose to schizophrenia has to be considered. Identification of susceptibility genes will greatly facilitate investigation of factors that contribute to the disease process and may lead to early intervention and prevention.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos Psicóticos
/
Cromosomas Humanos Par 21
/
Deleción Cromosómica
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Acta Psychiatr Scand
Año:
2002
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos