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Penicillin tolerance amongst non-toxigenic Corynebacterium diphtheriae isolated from cases of pharyngitis.
von Hunolstein, C; Scopetti, F; Efstratiou, A; Engler, K.
Afiliación
  • von Hunolstein C; Laboratorio di Batteriologia e Micologia Medica, Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, Italy. cris.v.h@iss.it
J Antimicrob Chemother ; 50(1): 125-8, 2002 Jul.
Article en En | MEDLINE | ID: mdl-12096018
Twenty-four strains of non-toxigenic Corynebacterium diphtheriae biotype gravis from the throats of patients with pharyngitis/tonsillitis were assayed for susceptibility to penicillin and erythromycin using determination of MIC, MBC and time-kill curves. There were no differences between the MICs of penicillin for susceptible and tolerant strains. All but one strain had penicillin MBCs > or = 2 mg/L. Seventy-one per cent (17/24) of the strains were tolerant to penicillin. In contrast, all strains were susceptible to erythromycin (MIC < or = 0.016 mg/L). These aspects should be considered when choosing the therapy for treating non-toxigenic C. diphtheriae pharyngitis/tonsillitis.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penicilinas / Resistencia a las Penicilinas / Faringitis / Corynebacterium diphtheriae / Antibacterianos Límite: Humans Idioma: En Revista: J Antimicrob Chemother Año: 2002 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penicilinas / Resistencia a las Penicilinas / Faringitis / Corynebacterium diphtheriae / Antibacterianos Límite: Humans Idioma: En Revista: J Antimicrob Chemother Año: 2002 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido