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Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues.
Uddman, Rolf; Möller, Sebastian; Nilsson, Torun; Nyström, Susanne; Ekstrand, Jonas; Edvinsson, Lars.
Afiliación
  • Uddman R; Department of Otorhinolaryngology, University Hospital, Malmö, Sweden. rolf.uddman@oron.mas.lu.se
Peptides ; 23(5): 927-34, 2002 May.
Article en En | MEDLINE | ID: mdl-12084524
mRNA encoding the human NPY Y1 and NPY Y2 receptors were detected in cerebral, meningeal, and coronary arteries using reverse transcriptase-polymerase chain reaction (RT-PCR). In addition, the trigeminal and superior cervical ganglia were positive for both receptors. In some arteries and in SK-N-MC cells only mRNA encoding the NPY Y1 was detected. Besides the expected NPY Y1 PCR products, an additional 97 bp longer amplicon originating from an alternative splicing event was found in most tissues studied. Antibodies directed against the NPY Y1 receptor revealed immunostaining mainly in the smooth muscle layer of blood vessels whereas antibodies against the NPY Y2 receptor showed immunostaining in nerve cell bodies.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Sanguíneos / Receptores de Neuropéptido Y Límite: Humans Idioma: En Revista: Peptides Año: 2002 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Sanguíneos / Receptores de Neuropéptido Y Límite: Humans Idioma: En Revista: Peptides Año: 2002 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos