Models for protein folding and nature's choice of protein as catalyst.
Biochemistry (Mosc)
; 67(5): 520-4, 2002 May.
Article
en En
| MEDLINE
| ID: mdl-12059770
The study of protein folding and unfolding pathways lends a fascinating dimension to protein biochemistry. Several models for protein folding have been postulated. Two powerful probes used in protein folding study are far UV-CD monitored stopped flow kinetics and pulse hydrogen exchange in conjunction with NMR. The formation of molten globule, which is an intermediate possessing secondary structure but not a well packed tertiary structure, is now emerging as a common feature on the folding pathway of many proteins. The molten globule is recognized by a class of molecules called chaperones which act as accelerators of protein folding. This article ends by elucidating why proteins are Nature's choice as catalysts.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pliegue de Proteína
/
Enzimas
/
Modelos Químicos
Idioma:
En
Revista:
Biochemistry (Mosc)
Año:
2002
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Estados Unidos