Fluorescence in situ hybridization (FISH)--application in research and diagnostics.
Folia Histochem Cytobiol
; 40(2): 107-8, 2002.
Article
en En
| MEDLINE
| ID: mdl-12056601
The methods of molecular cytogenetics, in particular fluorescence in situ hybridization (FISH), are widely applied in cytogenetics for identification of numerical and structural chromosomal abnormalities, which are difficult to detect by routine cytogenetic techniques. Due to many advantages, FISH is used in research (gene mapping, gene expression studies, interspecies chromosome homology), and clinical diagnostics (chromosomal aberrations analysis in pre- and postnatal diagnostics, oncology). The techniques of in situ hybridization (ISH) are often employed in addition to classical banding techniques, in case where banding pattern is not reliable. This paper focuses on particular clinical examples, where FISH was successfully used to identify structural and numerical chromosomal aberrations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hibridación Fluorescente in Situ
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Folia Histochem Cytobiol
Asunto de la revista:
HISTOCITOQUIMICA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Polonia
Pais de publicación:
Polonia