sigma(2) Receptors regulate changes in sphingolipid levels in breast tumor cells.

Crawford, Keith W; Coop, Andrew; Bowen, Wayne D

Crawford, Keith W; Coop, Andrew; Bowen, Wayne D.

Afiliación

Crawford KW; Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059, USA.

Eur J Pharmacol ; 443(1-3): 207-9, 2002 May 17.

Article en En | MEDLINE | ID: mdl-12044812

RESUMEN

sigma(2) Receptors induce apoptosis in various cell types. The sphingolipid, ceramide as well as the sphingoid bases are involved in cell proliferation. Sphingolipids of MCF-7/Adr- and T47D breast tumor cells were metabolically radiolabeled. The sigma(2) receptor agonists (+)-1R,5R-E-8-(3,4-dichlorobenzylidene)-5-(3-hydroxyphenyl)-2-methylmorphan-7-one (CB-184) and 1S,2R-(--)-cis-N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)-cyclohexylamine (BD737) caused dose-dependent increases in [(3)H]ceramide, with concomitant decreases in [(3)H]sphingomyelin. Both effects were attenuated by the novel sigma(2) receptor antagonist, N-phenethylpiperidine oxalate (AC927). sigma(2) Receptors may produce effects on cell growth and apoptosis by regulating the sphingolipid pathway.

Asunto(s)

Receptores sigma/fisiología; Esfingomielinas/metabolismo; Compuestos de Bencilideno/farmacología; Neoplasias de la Mama; División Celular; Ciclohexilaminas/farmacología; Humanos; Lactante; Morfinanos/farmacología; Oxalatos/farmacología; Piperidinas/farmacología; Pirrolidinas/farmacología; Receptores sigma/agonistas; Células Tumorales Cultivadas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esfingomielinas / Receptores sigma Límite: Humans / Infant Idioma: En Revista: Eur J Pharmacol Año: 2002 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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