Induction of quinone reductase by withanolides.

Misico, Rosana I; Song, Lynda L; Veleiro, Adriana S; Cirigliano, Adriana M; Tettamanzi, María C; Burton, Gerardo; Bonetto, Gloria M; Nicotra, Viviana E; Silva, Gloria L; Gil, Roberto R; Oberti, Juan C; Kinghorn, A Douglas; Pezzuto, John M

Misico, Rosana I; Song, Lynda L; Veleiro, Adriana S; Cirigliano, Adriana M; Tettamanzi, María C; Burton, Gerardo; Bonetto, Gloria M; Nicotra, Viviana E; Silva, Gloria L; Gil, Roberto R; Oberti, Juan C; Kinghorn, A Douglas; Pezzuto, John M.

Afiliación

Misico RI; Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Illinois 60612, USA.

J Nat Prod ; 65(5): 677-80, 2002 May.

Article en En | MEDLINE | ID: mdl-12027740

RESUMEN

Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5alpha-substituted derivatives exhibited weak activity. Preliminary studies were performed with compound 29 to evaluate enzyme-inducing capacity in multiple organ sites of BALB/c mice. Significant induction was observed in liver and colon, but not in lung, stomach, or mammary gland.

Asunto(s)

Brassicaceae/química; Carcinoma Hepatocelular/enzimología; Plantas Medicinales/química; Quinona Reductasas/biosíntesis; Solanaceae/química; Esteroides/química; Estilbenos/farmacología; Animales; Mama/enzimología; Colon/enzimología; Inducción Enzimática/efectos de los fármacos; Concentración 50 Inhibidora; Hígado/enzimología; Pulmón/enzimología; Ratones; Ratones Endogámicos BALB C; Estructura Molecular; Resonancia Magnética Nuclear Biomolecular; Estereoisomerismo; Esteroides/aislamiento & purificación; Esteroides/farmacología; Estómago/enzimología; Células Tumorales Cultivadas/efectos de los fármacos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Quinona Reductasas / Esteroides / Estilbenos / Carcinoma Hepatocelular / Brassicaceae / Solanaceae Límite: Animals Idioma: En Revista: J Nat Prod Año: 2002 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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