Skeletal muscle microvascular alterations in euthyroid and hypothyroid patients with autoimmune thyroid disease.
J Submicrosc Cytol Pathol
; 33(4): 425-32, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11989776
An electron microscopic study of skeletal muscle biopsies from euthyroid and hypothyroid patients with autoimmune thyroid disease (ATD) showed the existence of capillary alterations and a mononuclear cell infiltrate. Microvascular abnormalities included thickening and lamination of basement membrane, endothelial proliferation with progressive lumen occlusion, and hypertrophied pericytes. Capillary degeneration was also observed. Macrophages, and scarce lymphocytes and mast cells formed the cell infiltrate. This pathological picture is similar to that found in the muscular compromise of other autoimmune diseases, particularly Graves' hyperthyroidism. This study shows that patients with ATD may have skeletal muscle capillary abnormalities that could probably be related to autoimmunity and are independent of thyroid functional status.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiroiditis Autoinmune
/
Capilares
/
Músculo Esquelético
/
Hipotiroidismo
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Submicrosc Cytol Pathol
Asunto de la revista:
PATOLOGIA
Año:
2001
Tipo del documento:
Article
Pais de publicación:
Italia