[Effect of bilirubin derivative on HIV-1 in vitro].

Ye, Yao; Wang, Qi; Chen, Guomin; Zhang, Yi; Yan, Fang; Wang, Tianyu; Ma, Jinshi; Li, Zelin; Zeng, Yi

Ye, Yao; Wang, Qi; Chen, Guomin; Zhang, Yi; Yan, Fang; Wang, Tianyu; Ma, Jinshi; Li, Zelin; Zeng, Yi.

Afiliación

Ye Y; Institute of Virology, Chinese Academy Preventive Medicine, Beijing 100052, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi ; 16(1): 66-8, 2002 Mar.

Article en Zh | MEDLINE | ID: mdl-11986751

RESUMEN

BACKGROUND: To study the effect of DTB against HIV-1, for developing anti-HIV drugs. METHODS: Different concentration of DTB was added to cell culture system after viral inoculation, MTT staining method for viable cells (MTT assay) and p24 (ELISA) were used as markers to monitor the viral replication. RESULTS: The inhibition rates of DTB at concentrations 160, 80, and 40mg/ml were 93.0%, 56.2% and 18.1%, respectively. CONCLUSIONS: DTB could effectively inhibit HIV-1 in vitro.

Asunto(s)

Fármacos Anti-VIH/farmacología; Bilirrubina/farmacología; VIH-1/efectos de los fármacos; Bilirrubina/análogos & derivados; Relación Dosis-Respuesta a Droga; Humanos; Técnicas In Vitro

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / VIH-1 / Fármacos Anti-VIH Límite: Humans Idioma: Zh Revista: Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi Asunto de la revista: VIROLOGIA Año: 2002 Tipo del documento: Article País de afiliación: China Pais de publicación: China

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