The effect of retinoids and butyrate on the expression of CRX and IRBP in retinoblastoma cells.
Vision Res
; 42(8): 933-8, 2002 Apr.
Article
en En
| MEDLINE
| ID: mdl-11934446
We sought to determine whether differentiation agents such as retinoids and butyrate regulate transcript levels of interphotoreceptor retinoid binding protein (IRBP) and cone rod homeobox (CRX), a homeodomain transcription factor that regulates IRBP promoter activity. WERI-Rb1 retinoblastoma cells were treated with all-trans retinol, all-trans retinoic acid, or butyrate. IRBP and CRX mRNA levels were determined by quantitative RT-PCR. Butyrate at low concentrations increased both mRNA levels but suppressed them at higher concentrations. Retinoic acid had minimal effects. Retinol increased CRX mRNA over four fold. IRBP and CRX transcript levels are sensitive to butyrate and CRX expression is sensitive to retinol.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Retinoides
/
Butiratos
/
Proteínas de Unión al Retinol
/
Transactivadores
/
Proteínas de Homeodominio
/
Proteínas del Ojo
Límite:
Humans
Idioma:
En
Revista:
Vision Res
Año:
2002
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido