Muscle relaxing activity of Hyssopus officinalis essential oil on isolated intestinal preparations.
Planta Med
; 68(3): 213-6, 2002 Mar.
Article
en En
| MEDLINE
| ID: mdl-11914956
The muscle relaxing activity of the essential oil of Hyssopus officinalis L. (Lamiaceae) and some of its main components (isopinocamphone, limonene and beta-pinene) was studied on isolated preparations of guinea-pig and rabbit intestine. The essential oil and isopinocamphone inhibited the acetylcholine- and BaCl2-induced contractions in guinea-pig ileum in a concentration-dependent manner (IC50 42.4 microg/ml and 61.9 microg/ml to acetylcholine; 48.3 microg/ml and 70.4 microg/ml to BaCl2) whereas limonene or beta-pinene left tissue contraction unchanged. In guinea-pig ileum H. officinalis essential oil also blocked the contractions induced by CaCl2. In isolated rabbit jejunum the essential oil reduced the amplitude of spontaneous movements and decreased the basal tone; neither haemoglobin, methylene blue, N(omega)-nitro-L-arginine methyl ester (L-NAME) or propranolol blocked the myorelaxant effect.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aceites Volátiles
/
Lamiaceae
/
Monoterpenos
/
Íleon
/
Yeyuno
/
Relajación Muscular
Límite:
Animals
Idioma:
En
Revista:
Planta Med
Año:
2002
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Alemania