[Antimycotic treatment of pulmonary aspergilloma in patients without neutropenia]. / Antimykotische Therapie pulmonaler Aspergillome bei nicht neutropenischen Patienten.
Dtsch Med Wochenschr
; 127(10): 492-6, 2002 Mar 08.
Article
en De
| MEDLINE
| ID: mdl-11884987
BACKGROUND AND OBJECTIVE: Pulmonary aspergillomas are associated with a high morbidity and mortality. There are only very few data about non-surgical treatment in immunocompetent patients. METHODS: We evaluated 30 patients (19 male/11 female; mean age: 54 years) with pulmonary aspergillosis, their symptoms, treatment and outcome during a time period of 9 years. All patients had either definitive (18/60 %) or probable (12/40 %) aspergillosis with a cultural confirmation. RESULTS: Underlying diseases were tuberculosis (16/53 %), malignancy (8/30 %), COPD (15/50 %), pneumonia (3/10 %). Only five patients were immunocompromised (steroid medication: n = 4, chronic lymphatic leukemia: n = 1) All patients had a contraindication against surgery, 26 received antifungal treatment (mostly with voriconazole or itraconazole). The overall response was 61 %, there was an improvement of radiological signs in seven (23 %). Especially hemoptysis and dyspnea resolved. 12 patients died during the 9 years (40 %), nine from their underlying disease, three from the pulmonary aspergilloses (hemoptysis: n = 2, secondary invasive aspergillosis: n = 1). CONCLUSION: Pulmonary aspergilloma in its chronic form is a disease of patients with pulmonary disease but who are immunocompetent. Antifungal treatment seems to be a therapeutic option, if surgery is not possible.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aspergilosis Broncopulmonar Alérgica
/
Antifúngicos
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
De
Revista:
Dtsch Med Wochenschr
Año:
2002
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania