Does intravenous ondansetron affect gastric emptying of a solid meal, gastric electrical activity or blood hormone levels in healthy volunteers?

Netzer, P; Gaia, C; Lourens, S T; Reber, P; Wildi, S; Noelpp, U; Ritter, E P; Ledermann, H; Lüscher, D; Varga, L; Kinser, J A; Büchler, M W; Scheurer, U

Netzer, P; Gaia, C; Lourens, S T; Reber, P; Wildi, S; Noelpp, U; Ritter, E P; Ledermann, H; Lüscher, D; Varga, L; Kinser, J A; Büchler, M W; Scheurer, U.

Afiliación

Netzer P; Gastrointestinal Unit, University Hospital, Inselspital, Berne, Switzerland.

Aliment Pharmacol Ther ; 16(1): 119-27, 2002 Jan.

Article en En | MEDLINE | ID: mdl-11856086

RESUMEN

BACKGROUND: In previous studies, tropisetron has been shown to accelerate gastric emptying of a solid meal. However, it is uncertain whether other specific 5-hydroxytryptamine-3 receptor antagonists, such as ondansetron, also have a gastroprokinetic effect in humans. AIM: To evaluate the effect of ondansetron on gastric half-emptying time (T1/2) of a solid meal, gastric myoelectrical activity and hormone levels in 14 healthy volunteers. METHODS: In a placebo-controlled, randomized, crossover study, we investigated the effects of ondansetron (8 mg intravenously) on the gastric emptying of solids (by scintigraphy), gastric myoelectrical activity (by electrogastrography) and the post-prandial release of cholecystokinin, gastrin, human pancreatic polypeptide, gastric inhibitory polypeptide, vasoactive intestinal polypeptide, motilin, substance P and galanin. RESULTS: The average T1/2 values were 86 min and 85.5 min without lag time (P=0.082) and 92 min and 93 min with lag time (P=0.158) for the placebo and ondansetron treatments, respectively. The average T1/2 of female volunteers was significantly longer than that of male volunteers. The dominant gastric electrical frequency and hormone plasma concentrations were not altered by ondansetron. CONCLUSIONS: Ondansetron did not affect the gastric emptying of solids, the dominant gastric electrical frequency or the plasma concentrations of the analysed gastrointestinal peptides.

Asunto(s)

Vaciamiento Gástrico/efectos de los fármacos; Hormonas Gastrointestinales/sangre; Ondansetrón/farmacología; Antagonistas de la Serotonina/farmacología; Estómago/fisiología; Adulto; Estudios Cruzados; Ingestión de Alimentos; Electrofisiología; Femenino; Humanos; Infusiones Intravenosas; Masculino; Periodo Posprandial

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antagonistas de la Serotonina / Estómago / Ondansetrón / Vaciamiento Gástrico / Hormonas Gastrointestinales Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male Idioma: En Revista: Aliment Pharmacol Ther Asunto de la revista: FARMACOLOGIA / GASTROENTEROLOGIA / TERAPIA POR MEDICAMENTOS Año: 2002 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

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