Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).

Blasiak, J; Trzeciak, A; Gasiorowska, A; Drzewoski, J; Malecka-Panas, E

Blasiak, J; Trzeciak, A; Gasiorowska, A; Drzewoski, J; Malecka-Panas, E.

Afiliación

Blasiak J; Department of Molecular Genetics, University of Lodz, Poland.

Plant Foods Hum Nutr ; 57(1): 53-61, 2002.

Article en En | MEDLINE | ID: mdl-11855621

RESUMEN

The effects of natural compounds, vitamin C and quercetin, present in fruits and vegetables, on the DNA damaging activity of a food carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were examined using the comet assay. Vitamin C, at a concentration of 50 microM, inhibited MNNG-induced DNA damage in human lymphocytes. Quercetin, up to a concentration of 10 microM, increased the extent of DNA damage, but at concentrations above 10 microM decreased damage below control values. Furthermore, quercetin had a strong antioxidant activity against oxidative damage evoked by H2O2 at 10 microM. The results obtained suggest that vitamin C and quercetin may have anti- or pro-oxidative properties depending on the state of the cell.

Asunto(s)

Antioxidantes/farmacología; Ácido Ascórbico/farmacología; Daño del ADN/efectos de los fármacos; Metilnitronitrosoguanidina/farmacología; Quercetina/farmacología; Adulto; Cobre/farmacología; Frutas/química; Humanos; Peróxido de Hidrógeno/farmacología; Linfocitos/química; Verduras/química

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Ascórbico / Quercetina / Daño del ADN / Metilnitronitrosoguanidina / Antioxidantes Límite: Adult / Humans Idioma: En Revista: Plant Foods Hum Nutr Asunto de la revista: BOTANICA / CIENCIAS DA NUTRICAO Año: 2002 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Países Bajos

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