[Acute osteomyelitis in the child with sickle cell disease in a tropical zone: value of oral fluoroquinolones]. / Ostéomyélites aiguës de l'enfant drépanocytaire en zone tropicale: intérêt de l'utilisation des fluoroquinolones par voie orale.
Arch Pediatr
; 8(12): 1305-10, 2001 Dec.
Article
en Fr
| MEDLINE
| ID: mdl-11811024
AIM: This study was designed to assess the efficacy and the safety of fluoroquinolones in their compassionate use for acute osteomyelitis in children with sickle cell disease in a tropical country. PATIENTS AND METHODS: This study was non comparative, including twelve children (eight SS, three SC and one SEzerothalassemia) treated for acute osteomyelitis with oral ciprofloxacin or ofloxacin because of the following reasons: financial inability to afford conventional parenteral beta-lactams therapy (nine patients), refusal of hospitalization (two patients), and failure of conventional treatment (one patient). RESULTS: The mean age of patients was 9.5 +/- 2.6 years. The long bones were the predominantly site. Salmonella species were present in 75% of cases, followed by other enterobacteriaceae (16.7%), and Staphylococcus aureus (8.3%). Successful outcome occurred in all cases after three to four-weeks of treatment and 45 days of plaster immobilization. Transient bilateral Achilles tendon tendinitis was noted in a five-year-old patient. CONCLUSION: In economically developing countries, oral fluoroquinolones may be a therapeutic alternative for acute osteomyelitis in patients with sickle cell disease particularly in cases of financial hardship or failure with conventional therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteomielitis
/
Infecciones Bacterianas
/
Clima Tropical
/
Anemia de Células Falciformes
/
Antiinfecciosos
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Aspecto:
Patient_preference
Límite:
Child
/
Female
/
Humans
/
Male
País/Región como asunto:
Africa
Idioma:
Fr
Revista:
Arch Pediatr
Año:
2001
Tipo del documento:
Article
País de afiliación:
Togo
Pais de publicación:
Francia