Effects of fluconazole on viable cell count in experimental intraperitoneal Candida abscesses.
J Infect Chemother
; 6(3): 144-7, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-11810554
We investigated the effects of fluconazole in experimental intraperitoneal Candida abscesses in neutropenic mice treated with cyclophosphamide to assess a clinically appropriate method for the application of fluconazole in fungal infections in patients with neutropenia. The efficacy of fluconazole in fungal infection was investigated in treatments started immediately after Candida albicans inoculation and before C. albicans inoculation (preventive use of fluconazole). In this intraabdominal fungal abscess model, it was confirmed that fungi in already formed abscess were not reduced in number by fluconazole, even when those fungi were susceptible to fluconazole. Fluconazole was effective with both administration methods. We conclude from this study that the effect of the preventive use of fluconazole was equivalent to the effect when treatment was started immediately after fungal inoculation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Peritoneales
/
Candidiasis
/
Fluconazol
/
Absceso Abdominal
/
Antifúngicos
Límite:
Animals
Idioma:
En
Revista:
J Infect Chemother
Asunto de la revista:
MICROBIOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2000
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Países Bajos