Effect of antiphologistics on blood-brain barrier in lymphostatic encephalopathic and in normal rats.
Agents Actions
; 5(1): 57-61, 1975 Feb.
Article
en En
| MEDLINE
| ID: mdl-1180178
Injection of the tremorigenic alkaloid harmine into lymphostatic encephalopathic rats leads to a longer duration of tremor and higher brain concentrations than in sham-operated controls. In lymphostatic encephalopathic as well as in normal rats different antiphlogistics shorten the tremor duration and decrease harmine concentration in brain. The antiphlogistics do not influence the plasma concentration of harmine, its protein binding and its tremorend concentration in brain. The effect of antiphlogistics in lymphostatic encephalopathic rats is considered as a consequence of the reduced blood-brain barrier permeability. Obviously in sick animals the blood-brain barrier permeability for harmine is not increased; the prolonged harmine tremor and the increased alkaloid concentration in the brain are consequences of the impaired cerebral lymphatic drainage only.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encefalopatías
/
Barrera Hematoencefálica
/
Alcaloides
/
Harmina
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Agents Actions
Año:
1975
Tipo del documento:
Article
Pais de publicación:
Suiza