In vitro antioxidant and photo-oxidant properties of dipyridamole.
Int J Toxicol
; 20(6): 363-8, 2001.
Article
en En
| MEDLINE
| ID: mdl-11797818
The in vitro antioxidant and photo-oxidant activity of dipyridamole was studied by its effect on superoxide- and singlet oxygen-mediated photohemolysis and viability of neutrophils. Dipyridamole was found to be phototoxic when examined by the photohemolysis on human erythrocytes and on linoleic acid as lipid peroxidation model at concentrations above 3.0 x 10(-5) M. On the contrary, when lower concentrations (1.0 x 10(-5) to 1.0 x 10(-6) M) were used, dipyridamole showed a protector action against singlet oxygen-mediated photohemolysis by other phototoxic compounds like triamterene. This antioxidant property is proposed to result from quenching of triamterene mediated by fluorescence energy transfer. Auto-oxidation and fluorescence-energy transfer is clearly an important mechanism for protection for this drug.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fotólisis
/
Inhibidores de Agregación Plaquetaria
/
Dipiridamol
/
Hemólisis
/
Antioxidantes
Límite:
Humans
Idioma:
En
Revista:
Int J Toxicol
Asunto de la revista:
TOXICOLOGIA
Año:
2001
Tipo del documento:
Article
País de afiliación:
Venezuela
Pais de publicación:
Estados Unidos