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Effects of cyclazocine and scopolamine on swim-to-platform performance in rats.
Buckton, G; Zibrowski, E M; Vanderwolf, C H.
Afiliación
  • Buckton G; Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2, Canada.
Brain Res ; 922(2): 229-33, 2001 Dec 20.
Article en En | MEDLINE | ID: mdl-11743954
DL-Cyclazocine (0.5-2.0 mg/kg, i.p.) produced no impairment in rats' acquisition and retention of the behavior of swimming to a large visible platform in a water tank. However, cyclazocine produced a significant enhancement or potentiation of the impairment in swim-to-platform behavior produced by scopolamine. Since cyclazocine has previously been shown to abolish serotonin-dependent electrocortical activation (enabling it, in combination with central muscarinic blockade, to block all cortical activation), the results lend further support to the hypothesis that blockade of electrocortical activation produces dementia rather than sleep or coma as was previously believed.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escopolamina / Corteza Cerebral / Antagonistas Muscarínicos / Ciclazocina / Electroencefalografía / Aprendizaje / Antagonistas de Narcóticos Límite: Animals Idioma: En Revista: Brain Res Año: 2001 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escopolamina / Corteza Cerebral / Antagonistas Muscarínicos / Ciclazocina / Electroencefalografía / Aprendizaje / Antagonistas de Narcóticos Límite: Animals Idioma: En Revista: Brain Res Año: 2001 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos