On Trk for retrograde signaling.

Miller, F D; Kaplan, D R

Miller, F D; Kaplan, D R.

Afiliación

Miller FD; Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, H3A 2B4, Montreal, Quebec, Canada. freda.miller@mcgill.ca

Neuron ; 32(5): 767-70, 2001 Dec 06.

Article en En | MEDLINE | ID: mdl-11738023

RESUMEN

Target-derived neurotrophins like nerve growth factor (NGF) mediate biological effects by binding to and activating Trk neurotrophin receptors at nerve terminals. The activated Trk receptors then stimulate local effects at nerve terminals, and retrograde effects at neuronal cell bodies that often reside at considerable distances from the terminals. However, the nature of the retrograde signal has been mysterious. Recent experiments suggest that the major retrograde signal required for survival and gene expression consists of activated Trk itself. Remarkably, signaling by Trk may differ at the terminal versus the neuronal cell body as a consequence of the retrograde transport mechanism, thereby allowing NGF to not only promote growth locally, but to specifically support survival and gene expression retrogradely.

Asunto(s)

Transporte Axonal/fisiología; Factor de Crecimiento Nervioso/metabolismo; Receptor trkA/fisiología; Transducción de Señal/fisiología; Animales; Activación Enzimática/fisiología; Humanos; Receptores de Factor de Crecimiento Nervioso/fisiología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transporte Axonal / Transducción de Señal / Receptor trkA / Factor de Crecimiento Nervioso Límite: Animals / Humans Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2001 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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