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Antimycobacterial plant terpenoids.
Cantrell, C L; Franzblau, S G; Fischer, N H.
Afiliación
  • Cantrell CL; U.S. Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, Illinois 61604, USA. cantrellc@mail.ncaur.usda.gov
Planta Med ; 67(8): 685-94, 2001 Nov.
Article en En | MEDLINE | ID: mdl-11731906
Abstract. Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, is the leading killer among all infectious diseases worldwide and is responsible for more than two million deaths annually. For over thirty years no antitubercular agents with new mechanisms of action have been developed. The recent increase in the number of multi-drug resistant clinical isolates of M. tuberculosis has created an urgent need for the discovery and development of new antituberculosis leads. This review covers recent reports on plant-derived terpenoids that have demonstrated moderate to high activity in in vitro bioassays against M. tuberculosis. In this review, mono-, sesqui-, di- and triterpenes, and sterols, their structural analogs and semisynthetic derivatives will be discussed, with particular emphasis on the structural features essential for antimycobacterial activity.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terpenos / Tuberculosis / Preparaciones de Plantas / Fitoterapia / Antituberculosos Límite: Humans Idioma: En Revista: Planta Med Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terpenos / Tuberculosis / Preparaciones de Plantas / Fitoterapia / Antituberculosos Límite: Humans Idioma: En Revista: Planta Med Año: 2001 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania