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Endometrial histologic changes in post-menopausal breast cancer patients using tamoxifen.
Marchesoni, D; Driul, L; Fabiani, G; Di Loreto, C; Cataldi, P; Mozzanega, B.
Afiliación
  • Marchesoni D; Department of Surgical Sciences, University of Udine, Udine, Italy. diego.marchesoni@dsc.uniud.it
Int J Gynaecol Obstet ; 75(3): 257-62, 2001 Dec.
Article en En | MEDLINE | ID: mdl-11728486
OBJECTIVE: The aim of this study was to evaluate the effect of tamoxifen on the endometrium of post-menopausal women with breast cancer and to examine the relationship between ultrasonography, hysteroscopy and histopathologic changes. METHOD: Included in this longitudinal study were 303 post-menopausal women taking 20 mg daily of tamoxifen. Hysteroscopy was performed in 83 patients with an endometrial thickness of only >or=5 mm and 34 with vaginal bleeding also. Forty-five asymptomatic patients (control group) underwent hysteroscopies. RESULT: The most frequent outcome in patients with endometrial thickness of only >or=5 mm was an atrophic endometrium in an empty cavity (79.5%) whereas simple hyperplasia (35.3%) was found in women with vaginal bleeding. Carcinoma was diagnosed in seven cases (5.9%). In the control group, no endometrial cancer was found. CONCLUSION: This study suggests that patients with a thickness >5 mm should be offered a whole hysteroscopic evaluation, whenever bleeding is reported.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamoxifeno / Neoplasias de la Mama / Neoplasias Endometriales / Posmenopausia / Antineoplásicos Hormonales / Endometrio / Mioma Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Int J Gynaecol Obstet Año: 2001 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamoxifeno / Neoplasias de la Mama / Neoplasias Endometriales / Posmenopausia / Antineoplásicos Hormonales / Endometrio / Mioma Tipo de estudio: Diagnostic_studies / Observational_studies Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Int J Gynaecol Obstet Año: 2001 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos